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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: NMR Biomed. 2018 Nov 26;32(10):e4018. doi: 10.1002/nbm.4018

FIGURE 11.

FIGURE 11

The hyperpolarized 13C label in [1-13C] pyruvate rapidly exchanges into a preexisting lactate pool. The C1 13C signal of lactate first increases as the label is transferred from pyruvate and then decreases due to T1 decay of the hyperpolarized magnetization. The kP and kL rate constants as well as the T1 values can be calculated by fitting the C1 13C signal intensities of pyruvate and lactate to the modified Bloch equations written for a two-site exchange. (Reproduced with permission from Reference 148)