Fig. 1.
Study design and urine specimen selection for participants from the MARBLES Study contributing urine specimens to this analysis. The total number of participants is indicated with ‘N′ and the total number of urine specimens is indicated by ‘n′. Each urine specimen collected was either a first morning void (FMV) or a 24-h specimen; each pooled sample comprised two or more specimens, including one or more FMV and may also include a 24-h specimen. The total number of urine specimens collected can be calculated by summing the number of specimens in each pooled sample.