Table 2.

Comparison of the IGHV, IGHD, and IGHJ subgroups and significantly different IGHV in our series of FL with those reported for B-LPDs and CD5-/IgM+normal B cells

IGH	FL (n = 138)	DLBCL (n = 103)	MCL (n = 807)	CLL (n = 7596)	SMZL (n = 133)	HCL (n = 102)	MM (n = 270)	WM (n = 58)	CD5-/IgM+(n = 206)
IGHV
1	5.1	16.5 **	15.5 **	23.8 **	30.1 **	14.7 *	15.6 **	6.9	13.1 *
2	2.9	1.9	1.5	3.4	0.8	2.9	6.3	0	1.9
3	63.0	43.7 **	51.6*	48.2 **	49.6 *	53.9	48.9 **	75.9	53.9
4	26.8	33.0	25.8	20.6	17.3	23.5	20.4	13.8	24.8
5	1.4	3.9	5.1	2.5	2.3	1.0	7.8	1.7	2.9
6	0	1.0	0.6	1.2	0	2.9	1.1	1.7	2.4
7	0	0	0	0.4	0	1.0	0	0	1.0
3–21	7.2	4.8	16.5 **	4.7	3.0	3.1	1.5 **	5.2	0 **
3–23	13.8	9.7	7.4 *	8.5 *	18.0	18.1	5.0 **	29.3 *	12.1
3–30	9.4	0 †	3.5 **	5.5	6.0	8.5	10.0	8.6	5.8
3–48	10.1	5.8	3.6 **	3.9 **	3.8	5.3	1.8 **	0 *	4.4 *
4–34	14.5	15.5	14.6	8.9 *	7.5	7.4	0.9 **	0 **	3.9 **
IGHD
1	9.6	10.7	10.6	8.2	5.2	12.7	7.6	27.3	6.4
2	24.8	21.4	17.4	19.6	15.5	12.7	24.2	4.5	21.2
3	36.8	35.9	34.2	40.3	46.6	41.2	25.8	18.2	37.2
4	12.0	5.8	8.5	6.3	7.8	6.9	10.6	13.6	10.9
5	4.0	9.7	8.3	8.8	9.5	6.9	13.6	9.1	10.3
6	12.8	14.6	20.3	15.9	15.5	18.6	12.1	27.3	10.3
7	0	1.9	0.6	0.7	0	1.0	6.1	0	3.8
IGHJ
1	0.8	3.9	0.6	1.8	1.5	2.9	1.4	4.4	1.0
2	2.4	4.8	3.5	2.3	0	3.9	1.4	8.9	2.0
3	11.9	12.6	7.6	9.9	14.3	9.8	17.8	13.3	8.0
4	47.6	44.7	43.7	13.3	37.6	46.1	53.4	35.6	55.0
5	17.5	12.6	15.0	10.5	19.5	12.7	8.2	13.3	10.0
6	19.8	21.4	29.6	32.3	27.1	24.5	17.8	24.4	24.0

Frequencies expressed as percentages. References for comparisons are as follows: DLBCL²¹, MCL⁴⁰, CLL⁴¹, SMZL⁴², HCL⁴³, MM⁴⁴, WM¹⁹, and normal B cells³⁹. Significant differences between FL and other B-LPDs or normal B cells are depicted in bold

MCL mantle cell lymphoma, CLL chronic lymphocytic leukemia, SMZL splenic marginal zone lymphoma, HCL hairy cell leukemia, MM multiple myeloma, WM Waldenström macroglobulinemia

^*P < 0.05, ^**P < 0.01