Table 3.
Univariate and multivariate analysis of factors influencing cumulative incidence of histological transformation (HT)
| Variable | HT (%) at 10 years | U (p-value) | M (p-value) | HR [95% CI] |
|---|---|---|---|---|
| FL grade | ||||
| I (reference) | 26.8% | 0.556 | — | — |
| II | 25.6% | 0.976 | 1.0 [0.4–2.7] | |
| IIIA | 28.6% | 0.126 | 3.7 [0.7–19.3] | |
| FLIPI | ||||
| Low (reference) | 27.2% | 0.834 | — | — |
| Intermediate | 26.0% | 0.393 | 0.6 [0.2–1.9] | |
| High | 20.1% | 0.677 | 1.3 [0.4–4.1] | |
| Never treated (yes) | 85.3% | 3.6 × 10−7 | 6.7 × 10−7 | 21.2 [6.3–70.7] |
| IGHV3-48 gene (yes) | 71.3% | 0.014 | 0.010 | 5.0 [1.5–17.2] |
CI confidence interval, M multivariate analysis, FLIPI follicular lymphoma international prognostic index, HT cumulative incidence of HT, HR hazard ratio, U univariate analysis