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. 2018 Aug 23;34(8):1349–1367. doi: 10.1007/s00467-018-4042-z

Table 2.

Proposed underlying mechanisms in the pathophysiology of C3 glomerulopathy based on the presence of different types of convertase-stabilizing nephritic factors

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Type of C3NeF Properdin-independent C3NeF Properdin-dependent C3NeF/C5NeF
Associated complement profile C3 consumption C3 consumption
C5 normal or slightly consumed C5 consumption
sC5b-9 normal sC5b-9 elevated
Disease association DDD C3GN
Comparative mouse model FH−/−/P−/− FH−/−

C3NeF C3 nephritic factor, C5NeF C5 nephritic factor, sC5b-9 soluble C5b-9, DDD dense deposit disease, C3GN C3 glomerulonephritis, FH factor H, P properdin