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. 2019 Jun 11;10:604. doi: 10.3389/fneur.2019.00604

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Copyright © 2019 Wei, Chang, Feng, Li, Zhang and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low serum IL-10 levels are a predictor of relapse for clinically isolated syndrome (CIS) patients. (A) There was a significantly higher proportion of patients with clinical relapse (R) during follow-up among low IL-10 (<1.3 pg/ml) CIS patients than among high IL-10 (≥1.3 pg/ml) CIS patients (70.0 vs. 30.0%, p < 0.001). (B) Kaplan–Meier curves show that the time to first relapse was shorter in CIS patients with low serum levels of IL-10 (log-rank, p = 0.001).