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. 2019 Jun 11;11:141. doi: 10.3389/fnagi.2019.00141

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Copyright © 2019 Lachen-Montes, González-Morales, Palomino, Ausin, Gómez-Ochoa, Zelaya, Ferrer, Pérez-Mediavilla, Fernández-Irigoyen and Santamaría.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dual-omic approach to characterize the OB molecular homeostasis between 2-month-old and 6-month-old Tg2576 mice. (A) An overview of the experimental workflow used in this study. (B) Differential molecular profiling detected by-omics in Tg2576 OBs (2 and 6 months of age). The OB protein expression levels of amyloid precursor protein (APP) at early Alzheimer’s disease (AD) stages in Tg2576 mice is shown. (C) Heat maps representing the degree of change for the differentially expressed proteins (Supplementary Table S2) between 2-and 6-month-old Tg2576 mice respect to wild-type (WT) littermates. Red and green, up- and down-regulated proteins, respectively. (D) Venn diagram for the differentially expressed genes detected in Tg2576 mice at both time points (Supplementary Table S1).