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. 2019 Jun 11;11:141. doi: 10.3389/fnagi.2019.00141

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Copyright © 2019 Lachen-Montes, González-Morales, Palomino, Ausin, Gómez-Ochoa, Zelaya, Ferrer, Pérez-Mediavilla, Fernández-Irigoyen and Santamaría.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulation of the APP functional interactome in Tg2576 mice at the level of OB. Adaptation of APP functional network in Tg2576 OBs at 2 months of age (A) and 6 months of age (B). Relationships between differential expressed genes/proteins and APP functional interactors are represented with blue lines. Continuous lines represent direct interactions, while discontinuous lines correspond to indirect functional interactions. Up-regulated molecules in red, and down-regulated molecules in green (See complete legend at: http://qiagen.force.com/KnowledgeBase/KnowledgeNavigatorPage#).