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. 2019 Jun 11;11:141. doi: 10.3389/fnagi.2019.00141

Figure 5.

Figure 5

Protein synthesis, and mitochondrial homeostasis are early compromised in Tg2576 at olfactory level. (A) Molecular network representing the up-regulation of ribosomal proteins (blue circles) in the OB of 2-month-old Tg2576. (B) Molecular network highlighting the dysregulation of specific components of the mitochondrial respiratory chain (Complex I, and Complex VI subunits) in the OB of 2-month-old Tg2576. (C) Time-dependent disruption of the olfactory Phb1 in Tg2576 mice. Phb expression was monitored by Western-blotting. (D) Time-dependent disruption of the olfactory Phb2 in Tg2576 mice. Phb expression was monitored by Western-blotting. Equal loading of the gels was assessed by stain-free digitalization. Panels show histograms of band densities. Data are presented as mean ± standard error of the mean (SEM) from three independent OB samples per group (*P < 0.05 vs. control group; **P < 0.01 vs. control group). Right graphs represent the expression of both Phb subunits during the aging process in WT and Tg2576 mice (2-, 6-, and 18-month-old).