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APP overproduction specifically modulates the activation of the SEK1/MKK4-stress-activated protein kinase (SAPK)/JNK axis in 6-month-old Tg2576 mice. Time-dependent expression of total and phosphorylated levels of SEK1 (A), SAPK/JNK (B), and protein kinase A (PKA; C). Equal loading of the gels was assessed by stain-free digitalization. Panels show histograms of band densities. Data are presented as mean ± SEM from three independent OB samples per group. *P < 0.05 vs. control group.
