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. 2019 Jun 11;11:141. doi: 10.3389/fnagi.2019.00141

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Copyright © 2019 Lachen-Montes, González-Morales, Palomino, Ausin, Gómez-Ochoa, Zelaya, Ferrer, Pérez-Mediavilla, Fernández-Irigoyen and Santamaría.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Olfactory SEK1/MKK4 and PKA are differentially activated across Braak stages in human AD. Levels and residue-specific phosphorylation of SEK1/MKK4 (A), and PKA (B) in the OB across AD phenotypes. Equal loading of the gels was assessed by Ponceau staining and hybridization with a GAPDH specific antibody. Right panels show histograms of band densities. Data are presented as mean ± SEM from five independent OB samples per group. *P < 0.05 vs. control group; ***P < 0.001 vs. control group. Representative Western blot gels are shown.