Figure 4.

Swiss mice infected with fecal slur from a patient with recurrent Clostridium difficile infection. (A) Oral administration of IP2S4 but not IP6 significantly reduced the acute inflammatory component of colitis compared with administration of myo-inositol. (B) Histological sections of excised colons. Inositol-treated mice (negative control) displayed overt colonic structural changes characterized by mucosal ulceration and overlying exudate, marked acute and chronic inflammatory infiltrate and submucosal edema. IP2S4- and IP6-treated mice had decreased mucosal damage and inflammatory infiltrate. Copyright ©2018. Reproduced with permission from Elsevier. Ivarsson ME, Durantie E, Huberli C, et al. Small-molecule allosteric triggers of Clostridium difficile toxin B auto-proteolysis as a AQ3 therapeutic strategy. Cell Chem Biol. 2018;26(1):17–26.e13.¹⁷⁵