Table 1.
Parameters | References | Conclusions |
---|---|---|
Cell types | (27, 30) | Distinct immunodominance patterns between CD4+ and CD8+ T cells |
Serotypes | (23, 28) | DENV3 showed a distinct immunodominance compared to DENV1,2, 4 serotypes |
Sequence of infection | (28) | The immunodominance patterns of T cells are shaped by the serotype infecting during the primary vs. secondary infection |
Primary vs. secondary infections | (21, 28, 31, 32) | During primary infection, serotype-specific epitopes are targeted by CD4+ and CD8+ T cells, although conserved epitopes are mostly targeted during secondary infections |
HLA alleles | (21, 23, 27, 33–35) | Magnitude, frequency, and breadth of T cell responses are associated with particular HLA alleles (protective or susceptible HLA restriction) |
Pre-existing immunity to DENV | (36–39) | DENV-immunity modulated ZIKV immunodominance patterns |