Table 1.

Parameters that influence the immunodominance of the T cell responses to DENV and ZIKV.

Parameters	References	Conclusions
Cell types	(27, 30)	Distinct immunodominance patterns between CD4+ and CD8+ T cells
Serotypes	(23, 28)	DENV3 showed a distinct immunodominance compared to DENV1,2, 4 serotypes
Sequence of infection	(28)	The immunodominance patterns of T cells are shaped by the serotype infecting during the primary vs. secondary infection
Primary vs. secondary infections	(21, 28, 31, 32)	During primary infection, serotype-specific epitopes are targeted by CD4+ and CD8+ T cells, although conserved epitopes are mostly targeted during secondary infections
HLA alleles	(21, 23, 27, 33–35)	Magnitude, frequency, and breadth of T cell responses are associated with particular HLA alleles (protective or susceptible HLA restriction)
Pre-existing immunity to DENV	(36–39)	DENV-immunity modulated ZIKV immunodominance patterns