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. 2019 Jun 11;10:1313. doi: 10.3389/fimmu.2019.01313

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Copyright © 2019 Tamburini, Elder, Finlon, Winter, Wessells, Borges and Lyons.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-expression of identified markers of immune suppression in primary breast cancers. Using the co-expression tool in cBioPortal to analyze mRNA (by RNASeq) levels of multiple markers reveals significant positive correlations between CD274 (the gene encoding for PD-L1) and (A) CD8A (B) PDCD1 (the gene encoding for PD-1) (C) LAG3 and (D) PDPN and (E) CD68. As well as between PDPN and CD68 (F). No correlation was observed with (G) PDGFA, a marker of fibroblasts, or its heterodimeric partner PDGFB (H). Statistical analyses are provided in Table 1.