Table 1.
Overview of MrgD receptor G protein-coupling under different conditions.
| G protein | Effect | Expression system or tissue | Ligand | References |
|---|---|---|---|---|
| Gq | Ca2+ influx | CHO cells + MrgD expression | ß-alanine | (6) |
| Gq | Ca2+ influx prolonged Ca2+ influx | HEK293 cells + MrgD expression + MrgD, MrgE coexpression | ß-alanine | (9) |
| Gq | Inhibition of KCNQ2/3 current | CHO cells + MrgD, KCNQ2/3 coexpression | ß-alanine | (15) |
| Gq | Partial inhibition of KCNQ2/3 current | Isolated DRG neurons | ß-alanine | (15) |
| Gq | Opening of CACC channels | oocytes + MrgD expression | ß-alanine | (16) |
| Gq | Decreased secretion, expression, and blood level of leptin | Perirenal adipose tissue | alamandine | (17) |
| Gs | Increased cAMP level | HEK293 cells + MrgD expression | Ang (1-7) | (18) |
| Gs | Increased cAMP level | Mesangial cells | Ang (1–7) | (18) |
| Gs(Gi) | Increased cAMP level | Primary mesangial and endothelial cells | Alamandine (higher doses) | (19) |
| Gi | Decreased cAMP level | CHO cells + MrgD expression | ß-alanine | (6) |
| Gi | Partial inhibition of KCNQ2/3 current | CHO cells + MrgD,KCNQ2/3 coexpression | ß-alanine | (15) |
| Gi | Inhibition of KCNQ2/3 current | Isolated DRG neurons | ß-alanine | (15) |
| Gi | Reversal of hyperhomocysteinamia-induced vascular dysfunction | Isolated abdominal aorta of New Zealand White rabbits | alamandine | (20) |
| Gi | Increase in blood pressure and sympathetic outflow | Microinjection in paraventricular nucleus of WKY and SHR rats | alamandine | (21) |