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. 2019 Jun 11;10:1257. doi: 10.3389/fimmu.2019.01257

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Copyright © 2019 Meira, Santos, Santo, Vasconcelos, Orge, Nonaka, Barreto, Caria, Silva, Barbosa-Filho, Macambira, Moreira and Soares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental design and exercise capacity of mice from the different experimental groups. (A) C57BL/6 mice were infected with 10³ Colombian strain T. cruzi trypomastigotes and treated during the chronic phase (6 months after infection) with 10 or 1 mg/kg of BA5 or benznidazole (100 mg/Kg), as indicated. (B,C) Distance run and time of exercise on a motorized treadmill. Values represent the means ± S.E.M. of 5 mice (naïve) or 10 mice (infected) per group. *P < 0.05 compared to vehicle-treated mice; ^#P < 0.05 compared to naive group. ^$P < 0.05 compared to benznidazole-treated group.