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. 2019 Jun 11;10:1257. doi: 10.3389/fimmu.2019.01257

Figure 2.

Figure 2

Reduction of inflammation and fibrosis by BA5 in cardiac tissue of chagasic mice. (A,E) heart sections of naive group. (B,F) heart sections of mice infected with T. cruzi and treated with vehicle. (C,G) heart sections of infected mice treated with 10 mg/Kg of BA5. (D,H) heart sections of mice infected and treated with 100 mg/Kg of benznidazole. (A–D) staining with hematoxylin & eosin. (E–H) staining with picrosirius red. (I) Inflammatory cells were quantified in heart sections of naive mice, vehicle-treated mice, BA5-treated mice or benznidazole-treated mice and integrated by area. (J) The expression of CD45 was evaluated by real-time qRT-PCR using cDNA samples prepared from mRNA extracted from hearts of experimental groups. (K) Fibrotic area is represented by percentage of collagen deposition in heart sections. Values represent the means ± S.E.M. of 5 mice (naïve) or 10 mice (infected) per group. *P< 0.05 compared to vehicle-treated mice; #P < 0.05 compared to naive group. $P < 0.05 compared to benznidazole-treated group. &P < 0.05 compared to mice treated with 10 mg/Kg for BA5.