Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Characteristic domain architecture and function of different MBD2 isoforms. MBD2a is the canonical isoform containing four domains while MBD2b lacks the N-terminal G/R-repeat due to the use of alternative start site during translation. On the other hand, the MBD2c isoform is formed due to the inclusion of an alternative third exon which produces a premature stop codon, and as a result, the MBD2c lacks the TRD and CC domains (Figure not drawn to the exact scale of the proteins).
