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. 2019 Jun 10;9:451. doi: 10.3389/fonc.2019.00451

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Copyright © 2019 Kervarrec, Samimi, Guyétant, Sarma, Chéret, Blanchard, Berthon, Schrama, Houben and Touzé.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morphological and immunohistochemical features of Merkel cell carcinoma: (A–C): hematein-phloxin-saffron staining revealed sheet of tumor cells with high mitotic activity (bar = 100 μm). Whereas, MCPyV-positive MCC (A,B) harbor scant cytoplasm, round nucleus and dusty chromatin, MCPyV negative tumor cells have more abondant clear cytoplasm and irregular nucleus (C). (D) chromogranin A cytoplasmic positivity, (E) cytokeratin 20 expression with paranuclear dot-pattern; (F) thyroid transcription factor-1 negativity; (G) membranous synaptophysin expression; (H) membranous CD56 expression; (I) special AT-rich sequence-binding protein 2 (SATB2) nuclear expression; (J) neurofilament expression with a dot-pattern; (K) terminal deoxy nucleotidyl transferase weak/moderate expression, (L) paired box 5 weak expression in tumor cells in comparison with intratumor lymphocytes (arrows).