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. 2019 Jun 10;9:451. doi: 10.3389/fonc.2019.00451

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Copyright © 2019 Kervarrec, Samimi, Guyétant, Sarma, Chéret, Blanchard, Berthon, Schrama, Houben and Touzé.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical and ultrastructural features of physiological Merkel cells: immunohistochemical staining of normal skin (A,B) revealed one Merkel cell located in the infundibulum of a hair follicle and coexpressing cytokeratin 20 (cytoplasmic expression in red) and SATB2 (nuclear expression in brown) (bar = 100 and 50 μm for A,B). Immunofluorescence staining of healthy skin revealed some Merkel cells expressing cytokeratin 20 (C,D), cytokeratin 8 (E) and Piezo2 (F) in the epidermis (C) and in hair follicles (D–F) (bar = 40 μm for C–F). Electron microscopy of a Merkel cell (G,H) revealed numerous dense-core granules (bars = 2 and 0.5 μm for G,H, respectively). A cropped region is shown in the inset (H).