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Microscopy features of MCC with divergent differentiation or intra-epidermal involvement [bars = 5 mm and 200 μm (A,B) and 100 μm (C,D). (A–C) combined MCC is characterized by the association of MCC with another differentiation subset, mainly squamous cell carcinoma (SCC). In some specimens, intra-epidermal neoplasia (IEN) such as Bowen disease, deriving from the non-neoplasic epidermis (NE) can be detected in tumor in close contact. (D) MCC harboring an intra-epidermal component.
