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. 2019 Jun 11;10:1325. doi: 10.3389/fimmu.2019.01325

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Copyright © 2019 Carenza, Calcaterra, Oriolo, Di Vito, Ubezio, Della Porta, Mavilio and Della Bella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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tSNE plots showing the clustering of peripheral blood DC subsets in healthy donors and MDS patients. Live CD45⁺/lin⁻/HLA-DR⁺ cells obtained from all unstimulated and stimulated samples of healthy donors (n = 16) and MDS patients (n = 10) were concatenated and displayed in a single tSNE dot plot (shown in gray). (A) tSNE plots showing clustered DC subsets in pooled unstimulated and stimulated samples of healthy controls (upper plot) compared with MDS patients (lower plot). Color code as indicated. Note the different geographic location of cDC1s in patients and controls. (B) The expression of CD141, costimulatory molecules (CD40, CD80, CD86), and immune checkpoints (PD-L1, ILT2, and TIM-3) was assessed on cDC1s from healthy donors (gray bars) and MDS patients (brown bars). Data expressed as MFI measured on concatenated files from all unstimulated samples. (C) tSNE plots showing clustered DC subsets in each single culture condition, in controls (left column) and MDS patients (right column). Note the different geographical location of unstimulated and TLR-stimulated cDC2s.