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. 2019 Jun 11;10:1323. doi: 10.3389/fimmu.2019.01323

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Copyright © 2019 Kimura, Mutoh, Hisamoto, Saito, Takahashi, Asakura, Ishii, Nakamura, Iida, Hase and Iwanaga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Airway M cells are pathologically induced in the tracheal epithelia associated with lymphoid infiltration in murine models of autoimmune disease. (A) Hematoxylin–eosin staining of the lung of non-obese diabetic (NOD) mice. Bars: 200 μm (left panel) and 50 μm (right panel). (B) Immunofluorescence images of CD3ε (magenta) and B220 (green) of lymphoid follicles associated with the bronchiole of NOD mice. Bars: 100 μm. (C,D) Immunofluorescence images of GP2 (magenta) and Tnfaip2 (green) (C) as well as GP2 (magenta) and RANK (green) (D) in the trachea of NOD mice. Images are representative of three independent experiments.