Table II.

The predicted drugs of DEGs.

Name	Accession number	Groups	Descriptiona
Captopril	DB01197	Approved	Captopril is a potent, competitive inhibitor of ACE and may be used in the treatment of hypertension.
Ramipril	DB00178	Approved	Ramipril is a prodrug belonging to the ACEI class of medications, may be used in the treatment of hypertension, myocardial infarction, stroke.
Labetalol	DB00598	Approved	Blocker of both α- and β-adrenergic receptors that is used as an antihypertensive.
Verapamil	DB00661	Approved	A calcium channel blocker that is a class IV anti-arrhythmia agent.
Mexiletine	DB00379	Approved, Investigational	Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Nicardipine	DB00622	Approved, Investigational	A potent calcium channel blockader with marked vasodilator action.
Propranolol	DB00571	Approved, Investigational	A widely used non-cardioselective β-adrenergic antagonist. Used in acute myocardial infarction, arrhythmias, hypertension.
Diltiazem	DB00343	Approved, Investigational	A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Amyl Nitrite	DB01612	Approved	An antihypertensive medicine. Amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine.
Propafenone	DB01182	Approved	An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak β-blocking activity.
Nifedipine	DB01115	Approved	Both a long and short-acting 1,4-dihydropyridine calcium channel blocker, preventing calcium-dependent myocyte contraction and vasoconstriction.
Labetalol	DB00598	Approved	Blocker of both α- and β-adrenergic receptors that is used as an antihypertensive.
Ramipril	DB00178	Approved	Ramipril is a prodrug belonging to the ACEI class of medications, may be used in the treatment of hypertension, myocardial infarction, stroke
Nimodipine	DB00393	Approved, Investigational	A calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation.
Benazepri	DB00542	Approved, Investigational	Can be converted into benazeprilat, a non-sulfhydryl ACEI. A medi cation used to treat hypertension, congestive heart failure and chronic renal failure.
Valsartan	DB00177	Approved, Investigational	Valsartan is an ARB that may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy.
Ephedrine	DB01364	Approved, Investigational	Affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Verapamil	DB00661	Approved	A calcium channel blocker that is a class IV anti-arrhythmia agent.
Digoxin	DB00390	Approved	Control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation.
Diltiazem	DB00343	Approved, Investigational	A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Timolol	DB00373	Approved	A β-adrenergic antagonist similar in action to propranolol. Timolol has been proposed as an antihypertensive, antiarrhythmic and anti angina agent.
Lisinopril	DB00722	Approved, Investigational	Lisinopril is a potent, competitive inhibitor of ACE.
Benazepril	DB00542	Approved, Investigational	Can be converted into benazeprilat, a non-sulfhydryl ACEI. A medi cation used to treat hypertension, congestive heart failure and chronic renal failure.
Penbutolol	DB01359	Approved, Investigational	Penbutolol is a drug in the β-blocker class used to treat hypertension.

^aThe description of drug was extracted from DrugBank. ACE, angiotensin-converting enzyme; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin-receptor blocker; DEG, differentially expressed genes.