Table III.
GO enrichment for the target genes of differentially expressed miRNAs.
| Cluster | ID | Description | P-value | Adjusted P-value | Gene ID |
|---|---|---|---|---|---|
| let-7j | GO:0016863 | Intramolecular oxidoreductase activity, transposing C=C bonds | 1.07×105 | 2.99×103 | Hsd3b6, Hsd3b3, Hsd3b2 |
| let-7j | GO:0008378 | Galactosyltransferase activity | 1.20×104 | 7.81×103 | B3gnt5, Galnt2, Fut9, Galnt12 |
| let-7j | GO:0008375 | Acetylglucosaminyltransferase activity | 2.42×104 | 7.81×103 | B3gnt5, Galnt2, Fut9, Galnt12 |
| let-7j | GO:0033764 | Steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 3.63×104 | 7.81×103 | Hsd3b6, Hsd3b3, Hsd3b2 |
| let-7j | GO:0016229 | Steroid dehydrogenase activity | 4.99×104 | 7.81×103 | Hsd3b6, Hsd3b3, Hsd3b2 |
| miR-196b-5p | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 2.53×104 | 2.42×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-196b-5p | GO:0000987 | Core promoter proximal region sequence-specific DNA binding | 3.44×104 | 2.42×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-196b-5p | GO:0001159 | Core promoter proximal region DNA binding | 3.60×104 | 2.42×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-196b-5p | GO:0000982 | Transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 3.76×104 | 2.42×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-196b-5p | GO:0008201 | Heparin binding | 5.62×104 | 2.90×102 | Fgfbp3, Lxn, Prss57, Ecm2 |
| miR-455-5p | GO:0008766 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase activity | 9.11×104 | 2.14×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-455-5p | GO:0018169 | Ribosomal S6-glutamic acid ligase activity | 9.11×104 | 2.14×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-455-5p | GO:0043773 | Coenzyme F420-0 gamma-glutamyl ligase activity | 9.11×104 | 2.14×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-455-5p | GO:0043774 | Coenzyme F420-2 alpha-glutamyl ligase activity | 9.11×104 | 2.14×102 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-455-5p | GO:0070735 | Protein-glycine ligase activity | 9.11×104 | 2.14×102 | Fgfbp3, Lxn, Prss57, Ecm2 |
| miR-338-3p | GO:0005096 | GTPase activator activity | 1.76×104 | 1.76×104 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-338-3p | GO:0030695 | GTPase regulator activity | 2.94×104 | 2.94×104 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-338-3p | GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 3.44×104 | 3.44×104 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-338-3p | GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 4.38×104 | 4.38×104 | Nr6a1, Hoxa7, Otx1, Hoxa5, Hand1, Sarnp |
| miR-338-3p | GO:0051082 | Unfolded protein binding | 4.88×104 | 4.88×104 | Fgfbp3, Lxn, Prss57, Ecm2 |
| miR-10b-3p | GO:0001106 | RNA polymerase II transcription corepressor activity | 4.20×103 | 3.67×103 | 76365 |
| miR-10b-3p | GO:0043175 | RNA polymerase core enzyme binding | 4.20×103 | 4.20×103 | Rprd1b |
| miR-10b-3p | GO:0048020 | CCR chemokine receptor binding | 5.59×103 | 5.59×103 | Ccl12 |
| miR-10b-3p | GO:0008009 | Chemokine activity | 6.81×103 | 6.81×103 | Ccl12 |
| miR-10b-3p | GO:0042379 | Chemokine receptor binding | 8.73×103 | 8.73×103 | Ccl12 |
| miR-92b-3p | GO:0008198 | Ferrous iron binding | 5.34×104 | 5.34×104 | Isca1, 432732 |
| miR-92b-3p | GO:0051537 | 2 iron, 2 sulfur cluster binding | 6.84×104 | 6.84×104 | Isca1, 432732 |
| miR-92b-3p | GO:0004364 | Glutathione transferase activity | 9.74×104 | 9.74×104 | Gsta2, Gm10639 |
| miR-92b-3p | GO:0051539 | 4 iron, 4 sulfur cluster binding | 1.62×103 | 1.62×103 | Isca1, 432732 |
| miR-1943-5p | GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | 1.57×105 | 1.57×105 | Atxn7l3, Usp22, 15361, Actn2; Hmga1-rs1, Rbm14 |
| miR-8112 | GO:0005109 | Frizzled binding | 1.14×105 | 1.14×105 | Ror2, Wnt9b, Wnt3a, Wnt2b |
GO, Gene ontology.