Table IV.

Kyoto Encyclopedia of Genes and Genomes pathway enrichment for the target genes of differentially expressed miRNAs..

Cluster	ID	Description	P-value	Adjusted P-value	Gene ID
let-7j	mmu00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2.85×103	4.75×102	B3gnt5, Fut9
let-7j	mmu00512	Mucin type O-glycan biosynthesis	3.06×103	4.75×102	Galnt2, Galnt12
miR-181c-5p	mmu00250	Alanine, aspartate and glutamate metabolism	1.37×102	4.53×102	Gfpt1
miR-181c-5p	mmu00520	Amino sugar and nucleotide sugar metabolism	1.81×102	4.53×102	Gfpt1
miR-181d-5p	mmu00250	Alanine, aspartate and glutamate metabolism	1.37×102	4.53×102	Gfpt1
miR-181d-5p	mmu00520	Amino sugar and nucleotide sugar metabolism	1.81×102	4.53×102	Gfpt1
let-7g-5p	mmu04550	Signaling pathways regulating pluripotency of stem cells	6.84×105	6.57×103	Smarcad1, Skil, Wnt16, Hand1, Hoxb1, Acvr1c
let-7g-5p	mmu00280	Valine, leucine and isoleucine degradation	1.92×104	9.22×103	Agxt2, Bcat1, Ehhadh, Acat1
let-7c-5p	mmu04550	Signaling pathways regulating pluripotency of stem cells	5.95×105	5.59×103	Smarcad1, Skil, Wnt16, Hand1, Hoxb1, Acvr1c
miR-222-3p	mmu04727	GABAergic synapse	6.35×104	2.35×102	Gng5, Gabra1, Gnb3
miR-222-3p	mmu05032	Morphine addiction	7.23×104	2.35×102	Gng5, Gabra1, Gnb3
miR-222-3p	mmu04724	Glutamatergic synapse	1.35×103	2.92×102	Gng5, Ppp3r1, Gnb3
miR-222-3p	mmu04371	Apelin signaling pathway	2.38×103	3.85×102	Agtr1a, Gng5, Gnb3
miR-222-3p	mmu04723	Retrograde endocannabinoid signaling	2.96×103	3.85×102	Gng5, Gabra1, Gnb3
miR-222-3p	mmu04151	PI3K-Akt signaling pathway	4.02×103	4.36×102	Ddit4, Gng5, Gnb3, Kit
miR-10b-3p	mmu05144	Malaria	6.08×103	2.68×102	Ccl12
miR-10b-3p	mmu05323	Rheumatoid arthritis	1.03×102	2.68×102	Ccl12
miR-10b-3p	mmu04657	IL-17 signaling pathway	1.13×102	2.68×1024	Ccl12
miR-10b-3p	mmu04933	AGE-RAGE signaling pathway in diabetic complications	1.24×102	2.68×102	Ccl12
miR-10b-3p	mmu05142	Chagas disease (American trypanosomiasis)	1.26×102	2.68×102	Ccl12
miR-10b-3p	mmu04668	TNF signaling pathway	1.34×102	2.68×102	Ccl12
miR-10b-3p	mmu05418	Fluid shear stress and atherosclerosis	1.76×102	2.78×102	Ccl12
miR-10b-3p	mmu04621	NOD-like receptor signaling pathway	2.08×102	2.78×102	Ccl12
miR-10b-3p	mmu05164	Influenza A	2.08×102	2.78×102	Ccl12
miR-10b-3p	mmu04062	Chemokine signaling pathway	2.42×102	2.90×102	Ccl12
miR-10b-3p	mmu05168	Herpes simplex infection	2.67×102	2.91×102	Ccl12
miR-10b-3p	mmu04060	Cytokine-cytokine receptor interaction	3.36×102	3.36×102	Ccl12
miR-8112	mmu04150	mTOR signaling pathway	1.40×102	8.55×104	Fzd8, Clip1, Wnt9b, Wnt3a, Wnt2b, Lpin1
miR-8112	mmu05217	Basal cell carcinoma	4.06×105	1.24×103	Fzd8, Wnt9b, Wnt3a, Wnt2b
miR-8112	mmu04916	Melanogenesis	4.17×104	8.48×103	Fzd8, Wnt9b, Wnt3a, Wnt2b
miR-8112	mmu04550	Signaling pathways regulating pluripotency of stem cells	1.36×103	1.60×102	Fzd8, Wnt9b, Wnt3a, Wnt2b
miR-8112	mmu05224	Breast cancer	1.64×103	1.60×102	Fzd8, Wnt9b, Wnt3a, Wnt2b
miR-8112	mmu04310	Wnt signaling pathway	1.72×103	1.60×102	Fzd8, Wnt9b, Wnt3a, Wnt2b
miR-8112	mmu04390	Hippo signaling pathway	2.10×103	1.60×102	Fzd8, Wnt9b, Wnt3a, Wnt2b
miR-8112	mmu00532	Glycosaminoglycan biosynthesis - chondroitin sulfate/dermatan sulfate	2.28×103	1.60×102	Chst15, B3galt6
miR-8112	mmu05200	Pathways in cancer	2.36×103	1.60×102	Fzd8, Wnt9b, Lpar1, Wnt3a, Wnt2b, Bcr
miR-8112	mmu04974	Protein digestion and absorption	3.98×103	2.43×102	Col2a1, Atp1a2, Col11a1
miR-8112	mmu05205	Proteoglycans in cancer	5.96×103	3.30×102	Fzd8; Wnt9b, Wnt3a, Wnt2b

miR, microRNA; mmu, Mus musculus.