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. 2019 May 9;20(1):33–40. doi: 10.3892/mmr.2019.10215

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — AKT and β-catenin signaling pathways serve crucial roles in miR-338-3p-mediated inhibition of A549 cell invasion (A and B) Inhibition of AKT signaling with perifosine resulted in a significant reduction of the number of invasive cells. (C and D) Inhibition of β-catenin signaling pathway with XAV939 resulted in an extensive decrease in invasive A549 cells. (E and F) Increased activity of β-catenin with BIO could rescue the inhibitory effect of miR-338-3p on A549 cell invasion. **P<0.01. Scale bar, 50 µm. Con, control; miR, microRNA; Peri, perifosine.