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. 2019 May 21;14:159–171. doi: 10.1016/j.omto.2019.05.003

Figure 2.

Figure 2

Oncolytic Activity of EEV or IMV Derived from SCR-Deleted VV against Ovarian Cancer Cell Lines

(A) Human ovarian cancer cell lines were treated with EEV from culture medium recovered from ovarian cancer cells infected with B5R or ΔSCR at an MOI of 0, 0.001, 0.01, 0.1, or 1, and they were photographed under a fluorescence microscope 5 days later. Scale bars, 1,500 μm. (B) Viability of ovarian cancer cells described in (A) after EEV infection. Data are presented as percent survival of mock-infected cells. **p < 0.01 (unpaired t test). (C) Human ovarian cancer cell lines were infected with whole-B5R or ΔSCR virus (IMV) at an MOI of 0, 0.001, 0.01, 0.1, or 1, and they were photographed as described in (A). (D) Viability of IMV-infected ovarian cancer cells shown in (C), evaluated as described in (B). Data in (B) and (D) are presented as means ± SD (n = 3).