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. 2019 May 9;20(1):41–48. doi: 10.3892/mmr.2019.10217

Figure 2.

Figure 2.

Effects of NRG1 on the expression levels of Snail and MMP-2. (A) NRG1 concentration-dependently increased the expression level of Snail. *P<0.05 48. vs. 24 h; **P<0.05 48, vs. 72 h. Expression levels of (B) Snail and (C) MMP-2 in the different groups of BMSCs. *P<0.05 BMSC-Sna + NRG group, vs. BMSC-NC + NRG, BMSC + NRG, BMSC-NC, and BMSC groups; **P<0.05 BMSC-Sna + NRG group, vs. BMSC-Sna group; #P<0.05 BSMC-Sna group, vs. BMSC-NC + NRG, BMSC + NRG, BMSC-NC, and BMSC groups. Data are presented as the mean ± standard deviation and P<0.05 was considered statistically significant. BMSC, bone marrow mesenchymal stem cells; Sna, Snail overexpression plasmid; NRG, neuregulin-1; NC, negative control; MMP-2, matrix metalloproteinase-2.