Figure 4.

EGFR mutation testing by ddPCR and ARMS-PCR in clinical plasma ctDNA samples. A total of 50 plasma ctDNA samples collected from EGFR tyrosine kinase inhibitor-naive non-small cell lung cancer patients were tested respectively by ddPCR and ARMs-PCR for the mutations of EGFR 19DELs, L858R, T790M. The testing results by ddPCR and ARMs-PCR of patient 7, 15 and 17 are illustrated. ddPCR, droplet digital polymerase chain reaction; EGFR, epidermal growth factor receptor; ARMS, amplification refractory mutation system; ct, circulating tumor; Pos, positive; Neg, negative.