Skip to main content
. 2019 May 22;20(1):735–744. doi: 10.3892/mmr.2019.10269

Figure 4.

Figure 4.

Downregulation of miRNA-22 regulates p38 MAPK/NF-κB signaling in the in vitro stroke model. (A) The potential microRNA-22 binding sites in the 3′-untranslated region (3′UTR) of p38 MAPK. (B) Luciferase activity levels. (C) Immunofluorescence for p-p38 protein expression (magnification, ×100). (D) p-p38, NF-κB, COX-2 and iNOS protein expression was examined by western blotting and quantified. ##P<0.01 vs. control negative group. miRNA-22, microRNA-22; Anti-22, downregulation of miRNA-22 group; MAPK, mitogen-activated protein kinase; NF, nuclear factor; p-, phosphorylated; COX, cyclooxygenase; iNOS, inducible NO synthase.