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p38 inhibitor reduces the proinflammatory effects of Anti-22 in model in vitro. p-p38, NF-κB, COX-2 and iNOS protein expression was determined by western blotting and statistically analyzed. ##P<0.01 vs. control negative group, **P<0.01 vs. downregulation of miRNA-22 group. Anti-22, downregulation of miRNA-22 group; Anti-22+p38 i, downregulation of miRNA-22 and p38 inhibitor group; p-, phosphorylated; NF, nuclear factor; COX, cyclooxygenase; iNOS, inducible NO synthase.
