Table III.

Overlapping genes at the four time points.

Tissue	Drug	Upregulated	Downregulated
Hippocampus	Ketamine Phencyclidine	Plin4, Sgk1, Gh, Txnip Klf2, Plin4, mtDNA_ND6	Ttr mtDNA_ND4L, Stk32c, Hebp1, mt-Nd4l, Prr7
	Memantine	Plin4, Klf2, Gadd45g, Mfsd2a, Ddit4, Cdkn1a, LOC240672, Dusp1, Sult1a1, Sgk1, Fos, Egr4, Txnip, Tsc22d3
Striatum	Ketamine	Plin4, Sgk1, Klf2, Il22ra1, Vmn1r78, Slc13a4, D7Zem2, Txnip, Ddit4, Olfr938, Kcne2, Star, 1500015O10Rik, Tmem26, Wfdc2, Spink8, Calml4, Olfr247, LOC380910, Ttr, Sostdc1, Cap2, Gm4758, Cox8b, Vmn1r89, Lbp, Col8a1, 932418N15Rik, Tmem28, Prr32, LOC672705, Folr1, Otx2, Aqp1, Clic6, Wdr86	Dcaf12l1, Meox1, Olfr837, Slc6a13, Crh, LOC100046930, Fut1, Krt31, Fam171a1, Olfr938, Olfr1168, Fam214b
	Phencyclidine	Plin4, Sgk1, Klf2, Kl, Enpp2, Olfr474, Dctn1, A030006E20Rik, D7Zem2, Aqp1, Fgf15, Cox8b, Wfdc2, Zg16, Folr1, LOC381105, Hbb-b2, Wdr86, Slc13a4, Ptgds, Crispld1, Osgin2, LOC383036, Igfbp2, Ces1a, Ctgf	Dcaf12l1, Aldh1a1, Fbxw15, Egr2, Cyp2c55, Egr4, Cldn5, Prr7, A230065H16Rik, LOC194360, Cic, Ethe1, Olfr1317
	Memantine	Plin4, Sgk1, Klf2, Nfkbia, E130102H24Rik, Cyp2c39, Pnpla2, Slc2a1, Gjb6, Gadd45g, Il22ra1, Megf9, Cdkn1a, Nostrin, BAI3, Ism1, Cfp, Ramp2, Txnip, Bcl6, Sult1a1, Tsc22d3, LOC100044968, 9930108O06Rik, Adipor2, Thbd, Ddit4	Dcaf12l1, LOC331511, Cyp2c55, Phyhip, LOC386233, Mid1ip1, Rpl27a-ps1, LOC381105, Cplx2, Calm3, Fam168b, Actb, Krt31, LOC241621, Pimreg,
		Megf9, Cdkn1a, Nostrin, BAI3, Ism1, Cfp, Ramp2, Txnip, Bcl6, Sult1a1, Tsc22d3, LOC100044968, 9930108O06Rik, Adipor2, Thbd, Ddit4	C330049H01Rik, LOC433476, Cldn5, LOC385068, Olfr1362, Hes5, Tmsb10, Rhbdd3, BC037112, LOC382092, LOC382237, LOC673501, LOC381132