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. 2019 Jun 12;12:153–159. doi: 10.2147/JIR.S210441

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© 2019 Jiang and Steinle.

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Epac1 can overcome recombinant human PKR (rhPKR) to reduce NLRP3 signaling. REC were grown in normal glucose (NG), high glucose (HG) or high glucose treated with the Epac1 agonist, rhPKR, and the Epac1 agonist+rhPKR. Panel A shows the time course for phosphorylation of PKR with the rhPKR. Panel B shows that the Epac1 increased Epac1 levels, while Panel C shows that the rhPKR increase PKR levels. Panel D-G shows NLRP3, caspase 1 and active IL-1β levels in the cells with the various treatments. *P<0.05 vs NG. #P<0.05 vs HG. $P<0.05 vs HG+rhPKR. Data are mean ± SEM. N=4.