Table 2.
Comparison of performance CPP detection methods
| Method | LOD | Detection range | Incubation time | Reference |
|---|---|---|---|---|
| Tubes CLIA | 2.25 pmol L−1 | 2.25–1215 pmol L−1 | 2 hrs | 13 |
| RIA | ― | 0–2500 pmol L−1 | >24 hrs | 14 |
| ELISA | 19.5 pmol L−1 | 19.5–1250 pmol L−1 | 4.5 hrs | 15,38 |
| Electrochemical assay | 37 pmol L−1 | 25–125 pmol L−1 | 5 mins | 16 |
| Fully automated CLIA | 6.25 pmol L−1 | 1.2–1250 pmol L−1 | 30 mins | This work |
Note: This would be a highlight that the incubation process was only 30 min for the proposed assay.
Abbreviations: CPP, copeptin; LOD, limit of detection; CLIA, Chemiluminescence immunoassay; RIA, radioimmunoassay; ELISA, enzyme-linked immunoassay.