Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 12;11:5459–5472. doi: 10.2147/CMAR.S196862

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Knockdown of IGF1R inhibits NB cell tumourigenesis. (A and B) IGF1R expression levels in IMR-32 (A) and SH-SY5Y (B) cells transfected with IGF1R shRNA and detected by Western blot. (C and D) Effect of IGF1R on IMR-32 (C) and SH-SY5Y (D) proliferation determined by MTT assay. (E–G) NB cell invasion determined by Transwell assay. (H and I) NB cell migration determined by wound healing assay. *P<0.05, **P<0.01 vs shNC group. All data are shown as the mean±SD based on three independent experiments.

Abbreviations: NB, neuroblastoma; IGF1R, insulin-like growth factor 1 receptor.