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. 2019 Jun 12;11:5459–5472. doi: 10.2147/CMAR.S196862

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© 2019 Wang et al.

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Knockdown of IGF1R attenuates cancer stem cell-like properties in NB cells. The sphere formation assay showed that IGF1R shRNA transfection dramatically reduced the ability of SH-SY5Y (A and B) and IMR-32 (E and F) cells to form spheres compared with the shNC group after 10-day incubation. The colony formation assay showed that much fewer and smaller colonies were observed when IGF1R was knocked down in both SH-SY5Y (C and D) and IMR-32 (G and H) cells. *P<0.05, **P<0.01 vs shNC group. All data are shown as the mean±SD based on three independent experiments.

Abbreviations: NB, neuroblastoma; IGF1R, insulin-like growth factor 1 receptor.