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. 2019 Jun 12;11:5459–5472. doi: 10.2147/CMAR.S196862

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© 2019 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Knockdown of IGF1R downregulates cancer stem cell markers in NB cells. (A–C) Expressions of the stem cell-related transcription factor in SH-SY5Y cells, including OCT4, SOX2, and NANOG detected by Western blot (A and B) and RT-PCR (C). (D–F) Expressions of the stem cell markers in SH-SY5Y cells, including Epcam, CD44, and CD133 detected by Western blot (D and E) and RT-PCR (F). *P<0.05, **P<0.01, ***P<0.001 vs shNC group. All data are shown as the mean±SD based on three independent experiments.

Abbreviations: NB, neuroblastoma; IGF1R, insulin-like growth factor 1 receptor.