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. 2019 Jun 11;10:605. doi: 10.3389/fphar.2019.00605

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Copyright © 2019 Buchwald

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fit of complex concentration-response data with the present model, Case IV: Fractional response curves of guinea-pig ileum contraction mediated by muscarinic receptor activation with carbachol (CCh; blue diamonds) and oxotremorine (Oxtr; red circles) in normal tissue and following inactivation through alkylation with phenoxybenzamine (PHB) at two different strengths (data after Kenakin, 1993; Kenakin and Christopoulos, 2011). Unified fit of all data with the present model is shown (lines) using a single γ amplification parameter for this pathway, single K _d affinity parameters for carbachol and oxotremorine, and the same q values for the PBA inactivation for both compounds (Table S4).