Difference in nonresponders (decreased GDF15 level postintervention) vs. responders (increased GDF15 level postintervention). Data were analyzed by two-way ANOVA. Raw value was used for plotting the figures, P value shown is the result of a repeated-measure linear model to estimate group differences in nonresponders vs. responders. Fat-free mass was not changed across the groups (A); fat mass was reduced in the combined groups, P < 0.001 (B). Subcutaneous fat to body weight ratio was significantly reduced in the responder group, P < 0.05 (C). Visceral fat to fat mass ratio was reduced in the responder group (D). Cholesterol and LDL were only decreased in the responder group, P < 0.001, P < 0.01, respectively (E and F). DEXA, dual-energy X-ray absorptiometry; DEXA FFM, fat-free mass measured by DEXA; DEXA FM, fat mass measured by DEXA; GDF15, growth differentiation factor 15; LDL, low density lipids; Post, after exercise intervention; Pre, before exercise intervention; SF:BW, subcutaneous fat:body weight; VF:FM, visceral fat:fat mass.