Fig. 6.

Effect of β-OH butyrate (βHB) on fasting hepatic gene expression in control and 3-hydroxy-3-methylglutaryl-CoA synthase II (HMGCS2) knockdown (KD) mice. A–F: hepatic peroxisome-proliferator activated receptor-α (PPAR-α) mRNA expression (A), uncoupling protein 2 (UCP2) mRNA expression (B), phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression (C), PEPCK enzymatic activity (D), carnitine palmitoyltransferase 1 (CPT1) mRNA (E), and CPT1 protein expression (F). Direct comparisons were made between injection (PBS or βHB) within antisense oligonucleotides (ASO)-treated group. NS, nonsignificant. P > 0.05. Number inside bar denotes n per group.