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Effect of β-OH butyrate (βHB) on fasting ketogenesis in control and 3-hydroxy-3-methylglutaryl-CoA synthase II (HMGCS2) knockdown (KD) mice. A–D: hepatic HMGCS2 mRNA expression (A), serum βHB (µM; B), hepatic acetoacetate (nmol/g liver tissue; C), and βHB (nmol/g liver tissue; D). Direct comparisons were made between injection (PBS or βHB) within antisense oligonucleotides (ASO)-treated group. NS, nonsignificant. P < 0.05. Number inside bar denotes n per group.
