Fig. 1.

Global Period 1 (Per1) knockout (KO) mice on a 129/sv background exhibit lower blood pressure than wild-type (WT) mice in response to high-salt diet plus desoxycorticosterone pivalate (DOCP). Mice described in our previous study (27) were given a high-salt (1% NaCl) diet followed by DOCP injection. Radiotelemetery recordings of mean arterial pressure were made for 72 h, and the averaged night (active period, 6 PM–6 AM) and day (rest period, 6 AM–6 PM) values are shown. Data were analyzed by two-way ANOVA; n = 6 WT mice and 5 KO mice.