Fig. 2.

The epithelial Na⁺ channel (ENaC) contributes to the hypertension observed in wild-type (WT) 129/sv mice on a normal diet. WT 129/sv male mice were placed in metabolic cages that were carefully spaced out to allow for telemetry recordings to be made at the same time as urine collections. Mice were treated with vehicle at 8 PM, and blood pressure (A) and urine Na⁺ excretion (B) were monitored for 4 h. At 8 PM the following day, the same mice were treated with benzamil and the same measurements were made. BW, body weight. Data are presented as means ± SE; n = 4 mice. *P < 0.05 by a paired t-test.