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. 2019 Jun 11;12:146. doi: 10.3389/fnmol.2019.00146

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Copyright © 2019 Tabbai, Moreno-Fernández, Zambrana-Infantes, Nieto-Quero, Chun, García-Fernández, Estivill-Torrús, Rodríguez de Fonseca, Santín, Oliveira, Pérez-Martín and Pedraza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of stress on hippocampal LPA concentrations. Restraint stress produced profound changes in (A) the hippocampal concentrations of total LPA and (B) all LPA species examined. (C) Restraint stress did not affect the percentage of relative abundance, but the EPM modified the profile of LPA species analyzed in the hippocampus. ^∗∗p ≤ 0.001 and ^∗∗∗p ≤ 0.0005 compared with the control group; ^##p ≤ 0.001 and ^###p ≤ 0.0005 compared with the EPM; ^$$$p ≤ 0.0005 compared with restraint stress. LPA 16:0; 18:0; 18:1, and 20:4 species [palmitic acid (16:0) and stearic acid (18:0)] [oleic (18:1), linoleic (18:2) and arachidonic acids (20:4)].