Fig. 5.

Details of activity state 4 and 15. The upper panel depicts the whole brain positive strength pattern or connectivity during this state the lower panel the brainstem-brain connectivity pattern, i.e. positive strength calculated based on connections between brainstem frois with cortical and subcortical frois but without connections only between subcortical and cortical frois. Please see intensity scaling. During activity state 4 the whole brain connectivity strength of brainstem and bilateral, inferior, lateral temporal lobes, orbitofrontal and thalamus regions is comparatively low compared to the rest of the brain but pronounced when the connectivity is restricted to brainstem-brain connections indicating a heightened degree of synchronization between these regions and a decreased degree of synchronization with other cortical/subcortical region Activity state 15 is the state with the highest brainstem connectivity and whole brain connectivity is characterized by strong brainstem superior temporal, insula connections. This pattern persists when only brainstem-brain connectivity is considered which indicates that the brainstem activity influences the activity in these regions.