Table 3.
Distribution of predicted enzymatic metabolizer phenotypes.
| Molecular phenotype | Function | NUDT15 | TPMT |
|---|---|---|---|
| Poor (%) | No function | No function | 1 (0.41) | NA |
| Intermediate (%) | Normal | No function | 48 (19.67) | 6 (2.46) |
| Normal | Decreased | NA | 1 (0.41) | |
| Normal (%) | Normal | Normal | 195 (79.92) | 237 (97.13) |
| Total (%) | 244 (100) | 244 (100) |
Molecular phenotypes were assigned using the PharmGKB haplotype set translational table. Star (*) allele genotype-to-phenotype correlation was adapted from information available at the Moriyama et al. (NUDT15) and the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline ( TPMT ); NA, not available.