Table 5.
Clinical associations autoantibody negative patients.
| Clinical Feature | Autoantibody Positive (%) | Autoantibody Negative (%) | p value | OR | 95% CI |
|---|---|---|---|---|---|
| Mechanic's hands | 31.4 | 7.1 | <0.001 | 0.17 | 0.11–0.25 |
| ILD | 39.5 | 12.2 | <0.001 | 0.21 | 0.16–0.28 |
| Periungual erythema | 49.9 | 19.9 | <0.001 | 0.25 | 0.18–0.35 |
| Rash (any DM)1 | 54.4 | 33.8 | <0.001 | 0.43 | 0.35–0.53 |
| Gottron's rash | 44.4 | 26.6 | <0.001 | 0.45 | 0.35–0.58 |
| Dysphagia | 45.6 | 28.4 | <0.001 | 0.47 | 0.36–0.62 |
| CTD Overlap | 18.4 | 9.7 | <0.001 | 0.48 | 0.35–0.66 |
| Heliotrope rash | 41.8 | 28.5 | <0.001 | 0.56 | 0.43–0.71 |
| Raynaud's phenomenon | 47.9 | 33.8 | <0.001 | 0.56 | 0.43–0.71 |
| Cardiac involvement | 12.5 | 7.5 | = 0.018 | 0.57 | 0.36–0.91 |
| V-sign rash | 37.1 | 27.4 | = 0.008 | 0.62 | 0.43–0.88 |
| Shawl sign rash | 28.0 | 19.3 | = 0.006 | 0.64 | 0.47–0.88 |
Results are shown on an analysis of the total cohort of 1637 patients comparing patients with at least one identifiable MSA or MAA on immunoprecipitation versus autoantibody negative. 1Rash (any DM): presence of any one of heliotrope, Gottron's, shawl sign or V sign dermatomyositis rash. ILD: Interstitial Lung Disease, CTD: Connective Tissue Disease, OR: Odds Ratio, CI: Confidence Interval.