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Comparison of the p38αMAPK:9 and p38αMAPK:10 complexes. Shown are the representation and the orientation of (A) compound 9 and (B) compound 10 in the kinase active site. Perspective is the same as for compound 11 in Figure 1B. The hydrogen bond interaction of the pyridine ring nitrogen with the amide backbone of the kinase is retained in all structures, and the vicinal naphthyl groups of compounds 9–11 occupy the proximal hydrophobic pocket.
