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Production scheme for compound 11. The regulatory starting material (RSM) was prepared as previously described.14 The intermediate compound was prepared by chlorination of the arylpyridazinone by POCl3 in acetonitrile (ACN).13,14,22 The product substance (API) was generated by treatment with 1-methylpiperazine in ethanol. The summary chemical and physical properties, including crystal structure (CCDC deposit numbers 1851508 and 1851509), are in Tables 8S and 9S.
